Living with Lewy body dementia (LBD) can be overwhelming, not just because of problems with memory or movement, but also because of symptoms like seeing or hearing things that are not really there (hallucinations) or developing strong beliefs that are not true (delusions). Hallucinations and delusions are common symptoms of Lewy body dementia and are called LBD psychosis. Psychosis is a medical condition where someone may lose touch with reality, but it does not mean the individual is violent or unsafe.

What is the study about?

The purpose of this research study is to evaluate an investigational drug for LBD psychosis that may help reduce these symptoms and allow researchers to learn more and move us closer to better treatment options.

What is involved?

If you decide to learn more about this study and consider volunteering, here is what you can expect:

• Screening period (up to 30 days): This period is used to determine eligibility for the study and will involve one clinic visit.
• Treatment period (6 weeks): Participants are randomly assigned to receive one of two different doses of the study medication or a placebo. While taking the study drug or placebo, participants will visit the clinic 5 times over 6 weeks.
• Assessments: Participants will be assessed for psychotic symptoms using standard clinical tools to assess presence and severity. The eligible participant will also undergo medical exams and lab testing throughout the trial.
• Care partner role: A care partner of yours will participate with you, including attending visits, helping with assessments, and remaining closely involved throughout the study.
• Costs covered: There is no cost to participate. All study visits, exams, and the assigned study drug are provided at no charge. Reimbursement for study-related expenses may also be available.
• Next steps: After the 6-week study, participants may be able to join an extension study where everyone receives the active medication.

Study doctors and staff will closely monitor participants and answer any questions that may arise throughout this research project.

Who can participate?

A person may be able to participate in this study if they:

• Are 55 to 84 years old
• Have been diagnosed with Lewy body dementia (either dementia with Lewy bodies or Parkinson’s disease dementia)
• Have experienced hallucinations and/or delusions for at least 2 months
• Have a care partner who can come to visits and help with study participation

Study Sites

Study Funder/Sponsor

This study is funded and sponsored by Acadia Pharmaceuticals, Inc.

For more information visit Illumera Study or contact:

Primary Contact

Name: Kristin Kidd

Phone Number: (434) 841-3162

Email: [email protected]

Alternate Contact

Name: Becky Howell

Phone Number: (848) 702-1886

Email: [email protected]